Tetrahedron

Enantioselective synthesis of martinelline chiral core and its diastereomer using asymmetric tandem Michael–aldol reaction

Y Yoshitomi, H Arai, K Makino, Y Hamada

Index: Yoshitomi, Yayoi; Arai, Hiromi; Makino, Kazuishi; Hamada, Yasumasa Tetrahedron, 2008 , vol. 64, # 51 p. 11568 - 11579

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Citation Number: 41

Abstract

Martinelline (1) and martinellic acid (2) constitute a small family of naturally occurring pyrroloquinoline alkaloids isolated from the roots of the tropical plant, Martinella iquitosensis, in 1995, as a nonpeptide bradykinin receptor antagonist ( Fig. 1). 1 Their structural features contain a unique pyrroloquinoline with fused tetrahydroquinoline and pyrrolidine rings and two prenyl guanidines. The intriguing biological activity of martinelline coupled with its unique structure has led several groups, ...

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