Design, synthesis and biological evaluation of 4-(1-(4 (sulphanilamide) phenyl)-3-(methyl)-1H-pyrazol-5-yl) dine urea and N-acyl derivatives as a soluble epoxide …

…, H Murtuza, S Phaniraj, S Shrivastava…

Index: Nimbarte, Vijaykumar D.; Murtuza, Hadianawala; Phaniraj, Sahishna; Shrivastava, Shweta; Naidu; Satheesh Kumar; Atcha, Krishnam Raju Medicinal Chemistry Research, 2014 , vol. 23, # 5 p. 2178 - 2197

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Citation Number: 2

Abstract

Abstract A series of novel sEH inhibitors containing a N-substituted piperidine ring [N-urea (8a–i)(9a–l) and amide derivatives (6a–l)(7a–l)] with pyrazole (a five-membered polar heterocycle) as a pharmacophore lead for sEH inhibition have been designed, synthesized and evaluated as novel analogues to reduce blood pressure elevation and inflammatory roles by acting as sEH inhibitors. The synthesized compound shows varying degree of ...