New HIV-1 replication inhibitors of the styryquinoline class bearing aroyl/acyl groups at the C-7 position: synthesis and biological activity

…, G Mbemba, D Desmaële, J d'Angelo

Index: Normand-Bayle, Marie; Benard, Christophe; Zouhiri, Fatima; Mouscadet, Jean-Francois; Leh, Herve; Thomas, Claire-Marie; Mbemba, Gladys; Desmaele, Didier; D'Angelo, Jean Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 18 p. 4019 - 4022

Full Text: HTML

Citation Number: 57

Abstract

Novel variants of HIV-1 replication inhibitors of the styrylquinoline class harboring aroyl/acyl group at the C-7 position have been synthesized. In sharp contrast with styrylquinolines bearing a carboxylic acid group at C-7, these compounds proved to be inactive toward HIV-1 integrase in in vitro assays.