Monatshefte für Chemie/Chemical Monthly

Novel High Energy Intermediate Analogues with Triazasterol-related Structures as Inhibitors of the Ergosterol Biosynthesis V [1]. Synthesis of Hexahydro-5H-imidazo [ …

E Gößnitzer, A Punkenhofer

Index: Goessnitzer, Edith; Punkenhofer, Asbjoern Monatshefte fur Chemie, 2003 , vol. 134, # 9 p. 1271 - 1282

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Citation Number: 4

Abstract

Summary. The synthesis of 1, 2, 6, 10b, 11, 12-hexahydro-5 H-imidazo [1′, 2′: 1, 2] pyrimido [4, 3-a] isoquinolines representing new types of 8, 13, 15-triazasteroids is described. The tetracyclic title compounds were prepared from 4-(2-hydroxyalkylamino) tetrahydro-2 H-pyrimidoisoquinolines, which furnish after conversion to the corresponding bromoalkylamino compounds and base-catalyzed intramolecular nucleophilic ...

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