Synthesis and structural characterization of 1-and 2-substituted indazoles: ester and carboxylic acid derivatives

…, H Ramos, IF Antunes, MJM Curto, MT Duarte, I Bento

Index: Teixeira, Fatima C.; Ramos, Helene; Antunes, Ines F.; Curto, M. Joao M.; Duarte, M. Teresa; Bento, Isabel Molecules, 2006 , vol. 11, # 11 p. 867 - 889

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Citation Number: 12

Abstract

Abstract: A series of indazoles substituted at the N-1 and N-2 positions with ester-containing side chains-(CH 2) n CO 2 R of different lengths (n= 0-6, 9, 10) are described. Nucleophilic substitution reactions on halo esters (X (CH 2) n CO 2 R) by 1 H-indazole in alkaline solution lead to mixtures of N-1 and N‑2 isomers, in which the N-1 isomer predominates. Basic hydrolysis of the ester derivatives allowed the synthesis of the corresponding indazole ...