Asymmetric Synthesis of a TRPV1 Antagonist via tert-Butanesulfinamide-Directed Reductive Amination with a Chromanone

ME Bellizzi, AV Bhatia, SC Cullen…

Index: Organic Process Research and Development, , vol. 18, # 2 p. 303 - 309

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Citation Number: 5

Abstract

... Organic Process Research & Development. ... Scheme 2). Despite crystallization of 6 and 1, monofluoro impurities were not rejected by the process, leading to ... With the ideal conditions for sulfinyl imine formation and reduction identified, the one-pot procedure was implemented on ...