Synthesis and Anti??herpetic Activity of Phosphoramidate ProTides
…, G Andrei, R Snoeck, J Balzarini, P Herdewijn
Index: Maiti, Munmun; Persoons, Leentje; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; Herdewijn, Piet ChemMedChem, 2013 , vol. 8, # 6 p. 985 - 993
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Citation Number: 3
Abstract
Abstract Among the many prodrug approaches aimed at delivering nucleoside monophosphates into cells, the phosphoramidate ProTide approach is one that has shown success, which has made it possible for some of the phosphoramidates to enter into clinical trials. Herein, we report the synthesis and antiviral activity of a series of phosphoramidate ProTides designed to bypass the thymidine kinase (TK) dependence of the parent ...
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