Synthesis and Structure Activity Relationship of Rigidized Indolyl Pyrrolidine Derivatives as 5-HT6 Receptor Ligands

R Nirogi, A Dwarampudi, V Bhatta…

Index: Nirogi, Ramakrishna; Dwarampudi, Adireddy; Bhatta, Venugopalarao; Kota, Laxman; Dubey Asian Journal of Chemistry, 2013 , vol. 25, # 16 p. 9293 - 9298

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Abstract

Abstract A novel series of rigidized indolyl pyrrolidine derivatives have been designed by constraining the tryptamine nitrogen through a and b carbons. All the synthesized derivatives have shown moderate affinities at 5-HT6R when tested in in vitro binding assay. Synthesis, structure activity relationship (SAR), pharmacokinetic profile and in vivo efficacy of a selected compound is the subject matter of this communication.