Synthesis of 2, 6-disubstituted benzylamine derivatives as reversible selective inhibitors of copper amine oxidases

F Lucchesini, M Pocci, S Alfei, V Bertini…

Index: Lucchesini, Francesco; Pocci, Marco; Alfei, Silvana; Bertini, Vincenzo; Buffoni, Franca Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 5 p. 1558 - 1567

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Citation Number: 2

Abstract

Abstract In order to obtain substrate-like inhibitors of copper amine oxidases (CAOs), a class of enzymes involved in important cellular processes as well as in crosslinking of elastin and collagen and removal of biogenic primary amines, we synthesized a set of benzylamine derivatives properly substituted at positions 2 and 6 and studied their biological activity towards some members of CAOs.