Synthesis and in vitro antitumor activity of novel scopoletin derivatives

W Liu, J Hua, J Zhou, H Zhang, H Zhu, Y Cheng…

Index: Liu, Wukun; Hua, Jie; Zhou, Jinpei; Zhang, Huibin; Zhu, Haiyang; Cheng, Yanhua; Gust, Ronald Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 15 p. 5008 - 5012

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Citation Number: 29

Abstract

Twenty scopoletin derivatives were developed by a systematic combinatorial chemical approach and their chemical structures were confirmed by MS, IR, 1H NMR spectra and elemental analysis. Primary screening against mammary (MCF-7 and MDA-MB 231) and colon (HT-29) carcinoma cells indicated that five compounds (8d, 8g, 8j, 11b and 11g) displayed high antitumor potencies with IC50 values below 20μM whereas scopoletin ...