Novel Symmetrical trans??Bis??Schiff Bases of N??Substituted??4??piperidones: Synthesis, Characterization, and Preliminary Antileukemia Activity Mensurations

…, HF Wang, J Zhu, DR Yang, J Xing…

Index: Sun, Chuan-Wen; Wang, Hai-Feng; Zhu, Jun; Yang, Ding-Rong; Xing, Jiahua; Jin, Jia Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 6 p. 1374 - 1380

Full Text: HTML

Citation Number: 3

Abstract

Abstract A series of novel symmetrical trans-bis-Schiff bases (11a, 11b, 11c, 11d, 11e, 11f, 11g, 11h, 11i, 11j, 11k, 11l, 11m) were designed and prepared as novel anticancer analogues, with the trans-configuration confirmed by X-ray diffraction. Preliminary inhibitory effects of these compounds on CML K562 cell growth were investigated, and the potential analogue 11e showed an excellent anti-leukemia activity (IC 50= 6.35 μg/mL), which is ...