. eta. 2-Pyrrole complexes as synthons to alkaloid derivatives

LM Hodges, J Gonzalez, JI Koontz…

Index: Hodges, L. Mark; Gonzalez, Javier; Koontz, Jason I.; Myers, William H.; Harman, W. D. Journal of Organic Chemistry, 1993 , vol. 58, # 18 p. 4788 - 4790

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Citation Number: 31

Abstract

Pyrroles represent an important class of synthons for alkaloids, providing up to four activated carbons in a heterocyclic ring. However, the pronounced tendency of pyrroles to undergo electrophilic attack at the a position often preempts reactivity at the biologically more signif- icant @ positions, and its tendency to rearomatize or polymerize in the presence of electrophiles limits the scope of useful addition reactiom2 Recently, we reported that T2-coordination of ...