Medicinal Chemistry Research

Synthesis and biological evaluation of novel AM80 derivatives as antileukemic agents

H Bian, J Feng, W Xu

Index: Bian, Haiyong; Feng, Jinhong; Xu, Wenfang Medicinal Chemistry Research, 2013 , vol. 22, # 1 p. 175 - 185

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Citation Number: 2

Abstract

Abstract A series of novel AM80 derivatives as antileukemic agents were synthesized and their structures were confirmed by IR, 1 H-NMR, and HR-MS spectra. All the target compounds were evaluated for in vitro antiproliferative activities against human leukemic HL- 60, NB4, and K562 cell lines. Among these derivatives, compound 4g showed much stronger antiproliferative activities against all the three human leukemic cell lines than the ...