3-Phenoxypyridine 1-oxides as anticonvulsant agents

MR Pavia, CP Taylor, FM Hershenson…

Index: Pavia; Taylor; Hershenson; Lobbestael; Butler Journal of Medicinal Chemistry, 1988 , vol. 31, # 4 p. 841 - 847

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Citation Number: 4

Abstract

The anticonvulsant activity of a series of 3-phenoxypyridine 1-oxides is described. An investigation carried out to optimize the activity/side effect ratio provided 4-methyl-3- phenoxypyidine 1-oxide, 3, as the derivative of choice. Overall, 3 has a pharmacological profile that is very similar to phenytoin. It exhibited significant anticonvulsant activity at doses that did not produce ataxia or sedation but caused increased spontaneous behavioral ...