Aryl indanyl ketones: Efficient inhibitors of the human peptidyl prolyl cis/trans isomerase Pin1

…, A Hessamian??Alinejad, S Houben…

Index: Daum, Sebastian; Erdmann, Frank; Fischer, Gunter; De Lacroix, Boris Feaux; Hessamian-Alinejad, Anahita; Houben, Sabine; Frank, Walter; Braun, Manfred Angewandte Chemie - International Edition, 2006 , vol. 45, # 44 p. 7454 - 7458

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Citation Number: 38

Abstract

Among the three families of human PPIases, the parvulinlike Pin1 is unique in its substrate specificity which has made it possible to specifically accelerate the cis–trans isomerization of PO3H2Ser (PO3H2Thr)–Pro bonds in short peptides and proteins.[4] Therefore, Pin1 interacts with and regulates many key phosphoproteins of the eukaryotic cell cycle, such as cyclin D1, p53, or β-catenin.[5] In several human cancer cell lines, the depletion of Pin1 ...