Synthesis and antilipolytic activities of quinolyl carbanilates and related analogs

…, U Chakraborty, K Bailey, S Sciortino…

Index: Musser; Chakraborty; Bailey; Sciortino; Whyzmuzis; Amin; Sutherland Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 62 - 67

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Citation Number: 14

Abstract

A series of quinolyl carbanilates wm prepared and tested as antilipolytic agents. These compounds inhibited production of glycerol from rat adipocytes and inhibited liberation of free fatty acids from triolein by canine cardiac triglyceride lipases. An extensive structureactivity relationship study indicated that 8-quinolyl4-methoxycarbanilate (1) contained features necessary for maximum potency in vitro. Substituting a benzofuranyl ...