The total synthesis of (+)-milbemycin β 3

R Baker, MJ O'Mahony, CJ Swain

Index: Baker, Raymond; O'Mahony, Mary J.; Swain, Christopher J. Journal of the Chemical Society, Chemical Communications, 1985 , # 19 p. 1326 - 1328

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Abstract

The milbemycins comprise a group of natural products isolated from cultures of Streptomyces B-41-146, of which milbemycin p3 (1) is the simplest.1 Interest in these com- pounds has increased since the isolation and identification of a structurally related series of macrolides, the avermectins.' ... The avermectins are effective against helminths and arthro- pods at very low concentrations, giving these compounds enormous potential as broad spectrum anti- ...