European Journal of Organic Chemistry

Simple RuCl3??Catalyzed Amide Synthesis from Alcohols and Amines

SC Ghosh, SH Hong

Index: Ghosh, Subhash Chandra; Hong, Soon Hyeok European Journal of Organic Chemistry, 2010 , # 22 p. 4266 - 4270

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Citation Number: 26

Abstract

Abstract A catalyst for the direct synthesis of amides from amines and alcohols, generated in situ from the economically attractive and readily available RuCl 3, an N-heterocyclic carbene (NHC), and pyridine, was developed. Of the screened NHC precursors, a less bulky one gave better yields for modestly sterically hindered substrates. In a search for the true catalytic intermediates, Grubbs catalysts were found to be active for the amidation of ...

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