New acridone-4-carboxylic acid derivatives as potential inhibitors of hepatitis C virus infection

…, AD Shved, AM Boguszewska-Chachulska

Index: Stankiewicz-Drogon, Anna; Palchykovska, Larisa G.; Kostina, Valentina G.; Alexeeva, Inna V.; Shved, Anatoly D.; Boguszewska-Chachulska, Anna M. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 19 p. 8846 - 8852

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Citation Number: 61

Abstract

A new class of compounds—acridone derivatives—was tested using the direct fluorometric helicase activity assay to determine the inhibitory properties of the derivatives towards the NS3 helicase of Hepatitis C virus (HCV). The compounds were also tested as putative transcription inhibitors of in vitro transcription based on the DNA-dependent T7 RNA polymerase. Most of the acridone derivatives tested were transcription inhibitors; however, ...