Hydrogen??Bond??Directed Catalysis: Faster, Regioselective and Cleaner Heck Arylation of Electron??Rich Olefins in Alcohols

Z Hyder, J Ruan, J Xiao

Index: Hyder, Zeynab; Ruan, Jiwu; Xiao, Jianliang Chemistry - A European Journal, 2008 , vol. 14, # 18 p. 5555 - 5566

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Citation Number: 46

Abstract

Abstract A general method for the regioselective Heck reaction of electron-rich olefins is presented. Fast, highly regioselective Pd-catalysed α-arylation of electron-rich olefins, vinyl ethers (1 a–d), hydroxyl vinyl ethers (1 e, f), enamides (1 g, h) and a substituted vinyl ether (1 i) has been accomplished with a diverse range of aryl bromides (2 a–r), for the first time, in cheap, green and easily available alcohols with no need for any halide scavengers or salt ...