Chinese Chemical Letters

… of (1S, 3′ R, 4′ S, 5′ S, 6′ R)-5-chloro-6-[(4-ethylphenyl) methyl]-3′, 4′, 5′, 6′-tetrahydro-6′-(hydroxymethyl)-spiro [isobenzofuran-1 (3H), 2′-[2H] pyran]-3 …

YH Liu, TM Fu, CY Ou, WL Fan, GP Peng

Index: Liu, Yong-Hai; Fu, Ting-Ming; Ou, Chun-Yan; Fan, Wen-Ling; Peng, Guo-Ping Chinese Chemical Letters, 2013 , vol. 24, # 2 p. 131 - 133

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Citation Number: 5

Abstract

A convenient approach for the preparation of (1S, 3′ R, 4′ S, 5′ S, 6′ R)-5-chloro-6-[(4- ethylphenyl) methyl]-3′, 4′, 5′, 6′-tetrahydro-6′-(hydroxymethyl)-spiro [isobenzofuran- 1 (3H), 2′-[2H] pyran]-3′, 4′, 5′-triol is developed. The targeted compound was synthesized from 2-bromo-4-methylbenzoic acid in nine steps and the isomers of undesired ortho-products were avoided during the preparation.