Journal of the American Chemical Society

Tandem Au-catalyzed 3, 3-rearrangement-[2+ 2] cycloadditions of propargylic esters: expeditious access to highly functionalized 2, 3-indoline-fused cyclobutanes

L Zhang

Index: Zhang, Liming Journal of the American Chemical Society, 2005 , vol. 127, # 48 p. 16804 - 16805

Full Text: HTML

Citation Number: 333

Abstract

The treatment of readily available propargylic indole-3-acetates with a catalytic amount of AuCl (PPh3)/AgSbF6 leads to tandem activations of the propargylic esters and the in situ generated allenylic esters, resulting in expeditious access to highly functionalized cyclobutanes with fused 2, 3-indoline and γ-lactone rings and an exocyclic E-double bond through sequential 3, 3-rearrangement and [2+ 2] cyclization.