New deoxynojirimycin derivatives as potent inhibitors of intestinal α-glucohydrolases

…, JB Ducep, MN Lalloz, A Ehrhard, C Danzin

Index: Lesur, Brigitte; Ducep, Jean-Bernard; Lalloz, Marie-Noelle; Ehrhard, Anne; Danzin, Charles Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 3 p. 355 - 360

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Citation Number: 9

Abstract

New N-alkyl, alkenyl and benzyl substituted DNJ derivatives incorporating a silicon atom in the substituent were synthesised. Kinetic parameters (K i, t 1 2) for inhibition of rat intestinal α-glucohydrolases as well as human lysosomal α-glucosidases were measured. New DNJ derivatives are potent and selective inhibitors of intestinal α-glucohydrolases.