Synthesis of spiro heterocyclic nitroxides derived from 4-piperidone

JFW Keana, VS Prabhu, DK Shen

Index: Keana, John F. W.; Prabhu, Vaikunth S.; Shen, DeKang Journal of Organic Chemistry, 1988 , vol. 53, # 10 p. 2365 - 2367

Full Text: HTML

Citation Number: 7

Abstract

agents for magnetic resonance imaging (MRI) application~.~,~ Nitroxides substituted with primary and secondary amino groups5 are particularly versatile owing to the possibility of further modification by way of acylation or alkylation reactions. Amino nitroxides also have potential as indicators of pH using electron spin resonance spectroscopy. 6 For MRI applications, resistance of the nitroxide group toward bioreduction is an important property ...