Synthesis and initial in vitro biological evaluation of two new zinc-chelating compounds: comparison with TPEN and PAC-1

…, SF Ali, RE Paulsen, TV Hansen, P Rongved

Index: Astrand, O. Alexander H.; Aziz, Gulzeb; Ali, Sidra Farzand; Paulsen, Ragnhild E.; Hansen, Trond Vidar; Rongved, Pal Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5175 - 5181

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Citation Number: 7

Abstract

Abstract The lipophilic, cell-penetrating zinc chelator N, N, N′, N′,-tetrakis (2- pyridylmethyl) ethylenediamine (TPEN, 1) and the zinc chelating procaspase-activating compound PAC-1 (2) both have been reported to induce apoptosis in various cell types. The relationship between apoptosis-inducing ability and zinc affinity (K d), have been investigated with two new model compounds, ZnA-DPA (3) and ZnA-Pyr (4), and ...

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