Design, synthesis and X-ray crystallographic studies of [7.3. 1] and [8.3. 1] macrocyclic FKBP-12 ligands

…, JV French, M Imbacuan, S Katoh, JH Tatlock…

Index: Babine, Robert E.; Bleckman; Littlefield, Ethel S.; Parge, Hans E.; Pelletier; Lewis, Cristina T.; French, Judy V.; Imbacuan, Michael; Katoh, Susumo; Tatlock, John H.; Showalter, Richard E.; Villafranca, J. Ernest Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 4 p. 385 - 390

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Citation Number: 13

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The design, synthesis, and structure activity relationships of a series of novel macrocyclic FKBP-12 ligands 1 are reported. The crystal structure of the complex between 7 and human FKBP-12 is reported and some SAR results are discussed based on this complex.

Synthesis of the Southern FGHI Ring System of Azaspiracid??1 and Investigation into the Controlling Elements of C28??and C36??Ketalization

[Zhou, Xiao-Ti; Lu, Liang; Furkert, Daniel P.; Wells, Charles E.; Carter, Rich G. Angewandte Chemie - International Edition, 2006 , vol. 45, # 45 p. 7622 - 7626]

Design, synthesis and X-ray crystallographic studies of [7.3. 1] and [8.3. 1] macrocyclic FKBP-12 ligands

Abstract

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