Molecular design of multifunctional food additives: antioxidative antifungal agents

K Nihei, A Nihei, I Kubo

Index: Nihei, Ken-Ichi; Nihei, Atsuko; Kubo, Isao Journal of Agricultural and Food Chemistry, 2004 , vol. 52, # 16 p. 5011 - 5020

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Citation Number: 27

Abstract

A series of alkyl 3, 4-dihydroxybenzoates (protocatechuates) was synthesized, and their fungicidal activity against Saccharomyces cerevisiae was assayed using a 2-fold serial broth dilution method. Nonyl and octyl 3, 4-dihydroxybenzoate were noted to be the most effective against this yeast with the minimum fungicidal concentration of 12.5 μg/mL each. The activity was found to correlate with the hydrophobic alkyl chain length. The time-kill curve study ...