Asymmetric reduction of 7, 8??difluoro??3??methyl??2H??1, 4??benzoxazine. Synthesis of a key intermediate of (S)??(??)??ofloxacin (DR??3355)

…, H Tsurumi, T Fujiwara, I Hayakawa

Index: Atarashi; Tsurumi; Fujiwara; Hayakawa Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 2 p. 329 - 331

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Citation Number: 54

Abstract

Feb-Маг 1991 Asymmetric Reduction of 7,8-Difluoro-3-methyl-2#-l,4-benzoxazine. Synthesis of a Key Intermediate of (5)-(-)-0floxacin (DR-3355) Shohgo Atarashi*, Hideaki Tsurumi, Toshihiro Fujiwara and Isao Hayakawa Research Institute, Daiichi Pharmaceutical Co., Ltd., 1-16-13, Kitakasai, Edogawaku, Tokyo 134, Japan Received July 18, 1990 An efficient, highly enantioselective synthesis of (S)-(-)-7,8-difluoro-2,3-dihydro-3-methyl-4#-l,4-ben- zoxazine, a key ...