Protein-mediated nitroaldol addition in aqueous media. Catalytic promiscuity or unspecific catalysis?

E Busto, V Gotor-Fernández…

Index: Busto, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente Organic Process Research and Development, 2011 , vol. 15, # 1 p. 236 - 240

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Citation Number: 44

Abstract

A high efficient and environmentally friendly procedure for the production of aromatic and heteroaromatic β-nitroalcohols has been developed. This synthetic approach involves the condensation of an appropriate aldehyde with 1-nitroalkanes in aqueous media using as catalyst the inexpensive carrier protein Bovine serum albumin (BSA). According to the experimental data, the Henry reaction between aromatic aldehydes and nitroalkanes in ...