Syntheses of 7??(2??Hydroxy??1??phenylethyl)??and 7??(2??Hydroxy??2??phenylethyl) guanine, DNA Adducts Derived from Styrene 7, 8??Oxide

J Novák, I Linhart, H Dvorˇáková

Index: Novak, Jan; Linhart, Igor; Dvorakova, Hana European Journal of Organic Chemistry, 2004 , # 12 p. 2738 - 2746

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Citation Number: 8

Abstract

Abstract 7-(2-Hydroxy-1-phenylethyl)-and 7-(2-hydroxy-2-phenylethyl) guanines are important DNA adducts which can be used as markers of exposure to styrene. Two synthetic routes leading to these compounds are presented using allyl-protected bromohydrins as synthetic equivalents of styrene oxide to alkylate 2-amino-6-chloropurine or 7-methyl-10-oxo- 9, 10-dihydropyrimido [1, 2-a] purine as precursors to guanine.(© Wiley-VCH Verlag ...