Glutathione conjugation of the cytostatic drug ifosfamide and the role of human glutathione S-transferases

HAAM Dirven, L Megens, MJ Oudshoorn…

Index: Dirven; Megens; Oudshoorn; Dingemanse; Van Ommen; Van Bladeren Chemical Research in Toxicology, 1995 , vol. 8, # 7 p. 979 - 986

Full Text: HTML

Citation Number: 64

Abstract

Development of drug resistance against alkylating cytostatic drugs has been associated with higher intracellular concentrations of glutathione (GSH) and increased expression of glutathione S-transferase (GST) enzymes. Therefore, enhanced detoxification by the glutathione/glutathione S-transferase pathway has been proposed as a major factor in the development of drug resistance toward alkylating agents. In this paper we describe 31P ...