An amphiphilic dendrimer for effective delivery of small interfering RNA and gene silencing in vitro and in vivo

…, X Liu, AL Bolcato??Bellemin, Y Wang, C Liu…

Index: Yu, Tianzhu; Liu, Xiaoxuan; Bolcato-Bellemin, Anne-Laure; Wang, Yang; Liu, Cheng; Erbacher, Patrick; Qu, Fanqi; Rocchi, Palma; Behr, Jean-Paul; Peng, Ling Angewandte Chemie - International Edition, 2012 , vol. 51, # 34 p. 8478 - 8484

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Citation Number: 106

Abstract

The potent ability of small interfering RNA (siRNA) to specifically and efficiently inhibit the expression of complementary RNA transcripts offers a promising alternative therapeutic approach for various diseases.[1] However, the major challenge facing siRNA-based therapy is the requirement of a safe and efficient delivery system for the siRNA.[2] Although viral vectors are highly efficient, their potential inflammatory, immunogenic, and mutagenic ...