α??Alkylation of Carbonyl Compounds by Direct Addition of Alcohols to Enol Acetates

Y Nishimoto, Y Onishi, M Yasuda…

Index: Nishimoto, Yoshihiro; Onishi, Yoshiharu; Yasuda, Makoto; Baba, Akio Angewandte Chemie - International Edition, 2009 , vol. 48, # 48 p. 9131 - 9134

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Citation Number: 38

Abstract

The catalytic α-alkylation of carbonyl compounds has contributed remarkably to the development of organic synthesis, and the reaction of enolate derivatives with alkyl electrophiles is a powerful alkylation method.[1] Alcohols are appealing electrophiles, as they are plentiful and readily synthesized; however, the direct use of alcohols is effectively prevented by the fact that the hydroxy group is a particularly poor leaving group, and it ...