Tetrahedron Letters

Iron (III) tosylate catalyzed synthesis of 3, 4-dihydropyrimidin-2 (1H)-ones/thiones via the Biginelli reaction

JT Starcevich, TJ Laughlin, RS Mohan

Index: Starcevich, Jacob T.; Laughlin, Thomas J.; Mohan, Ram S. Tetrahedron Letters, 2013 , vol. 54, # 8 p. 983 - 985

Full Text: HTML

Citation Number: 34

Abstract

The synthesis of dihydropyrimidinones and dihydropyrimidine thiones has attracted interest due to their biological activities. A common method for their synthesis is the Biginelli reaction, which is a one-pot condensation of an aryl aldehyde, urea (or thiourea), and ethyl acetoacetate. The Biginelli reaction is typically catalyzed by a Brønsted or Lewis acid. However, many of these catalysts such as BF3· Et2O and AlCl3 are corrosive and/or toxic. ...

Related Articles:

N-Sulfonic acid poly (4-vinylpyridinium) chloride as a highly efficient and reusable catalyst for the Biginelli reaction

[Shirini, Frahad; Abedini, Masoumeh; Pourhasan-Kisomi, Reyhaneh Chinese Chemical Letters, 2014 , vol. 25, # 1 p. 111 - 114]

α-Chlorobenzyl Isocyanates in a New Synthesis of 3, 4-Dihydropyrimidin-2 (1H)-ones

[Vovk; Sukach Russian Journal of Organic Chemistry, 2005 , vol. 41, # 8 p. 1240 - 1241]

Aluminium Nitrate Nonahydrate (Al (NO3) 3⋅ 9 H2O): An Efficient Oxidant Catalyst for the One??Pot Synthesis of Biginelli Compounds from Benzyl Alcohols

[Kolvari, Eskandar; Zolfigol, Mohammad Ali; Mirzaeean, Maryam Helvetica Chimica Acta, 2012 , vol. 95, # 1 p. 115 - 119]

Aluminium Nitrate Nonahydrate (Al (NO3) 3⋅ 9 H2O): An Efficient Oxidant Catalyst for the One??Pot Synthesis of Biginelli Compounds from Benzyl Alcohols

[Kolvari, Eskandar; Zolfigol, Mohammad Ali; Mirzaeean, Maryam Helvetica Chimica Acta, 2012 , vol. 95, # 1 p. 115 - 119]

More Articles...