Tetrahedron: Asymmetry

A new convenient approach to chiral β-aryl (heteroaryl) alkylamines

VG Nenajdenko, AS Karpov, ES Balenkova

Index: Nenajdenko, Valentine G; Karpov, Alexei S; Balenkova, Elizabeth S Tetrahedron Asymmetry, 2001 , vol. 12, # 18 p. 2517 - 2527

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Citation Number: 40

Abstract

Chiral β-aryl (heteroaryl) alkylamines have been prepared from N-tosyl alkylaziridines via regiospecific nucleophilic ring opening and subsequent desulfonylation in good to excellent yields. The corresponding aziridines are easily obtained from commercially available (S)-α- amino acids, so this method is the first effective route to asymmetric β-aryl (heteroaryl) alkylamines.

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