Synthesis of deuterium labeled ketamine metabolite dehydronorketamine-d 4

RS Sulake, C Chen, HR Lin, AC Lua

Index: Sulake, Rohidas S.; Chen, Chinpiao; Lin, Huei-Ru; Lua, Ahai-Chang Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5719 - 5721

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Citation Number: 4

Abstract

A convenient synthesis of ketamine metabolite dehydronorketamine-d4, starting from commercially available deuterium labeled bromochlorobenzene, was achieved. Key steps include Grignard reaction, regioselective hydroxybromination, Staudinger reduction, and dehydrohalogenation.