Journal of Fluorine Chemistry

Self-disproportionation of enantiomers of 3, 3, 3-trifluorolactic acid amides via sublimation

M Yasumoto, H Ueki, VA Soloshonok

Index: Yasumoto, Manabu; Ueki, Hisanori; Soloshonok, Vadim A. Journal of Fluorine Chemistry, 2010 , vol. 131, # 2 p. 266 - 269

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Citation Number: 32

Abstract

Preparation of racemic and enantiomerically enriched N-phenyl-and N-benzyl-3, 3, 3- trifluorolactic acid amides has been developed. These compounds were found to have substantial magnitude of the self-disproportionation of enantiomers (SDE) via sublimation. For example, when N-phenyl-3, 3, 3-trifluorolactic acid amide of 87% ee was sublimed (12h) from a Petri dish at 80° C open to the atmosphere, the enantiomeric excess of the ...