A new route to 3-acyl-2-aminobenzofurans: palladium-catalysed cycloisomerisation of 2-(cyanomethyl) phenyl esters

M Murai, K Miki, K Ohe

Index: Murai, Masahito; Miki, Koji; Ohe, Kouichi Chemical Communications, 2009 , # 23 p. 3466 - 3468

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Citation Number: 18

Abstract

Transition metal-catalysed addition reactions to nitriles have received considerable attention as a potential tool for the synthesis of amines and amides. 1–4 We recently reported the copper-catalysed pyrrolinone synthesis from carbonyl-ene-nitriles and nucleophiles, in which hydration of a cyano moiety followed by dehydrative cyclisation (cycloisomerisation) produced 2-aza-2,4-cyclopentadienone as an intermediate. 5 Although several transition metal- ...