Aromatic lipoxin A4 and lipoxin B4 analogues display potent biological activities

TP O'Sullivan, KSA Vallin, ST Ali Shah…

Index: O'Sullivan, Timothy P.; Vallin, Karl S. A.; Shah, Syed Tasadaque Ali; Fakhry, Jerome; Maderna, Paola; Scannell, Michael; Sampaio, Andre L. F.; Perretti, Mauro; Godson, Catherine; Guiry, Patrick J. Journal of Medicinal Chemistry, 2007 , vol. 50, # 24 p. 5894 - 5902

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Citation Number: 58

Abstract

Lipoxins are a group of biologically active eicosanoids typically formed by transcellular lipoxygenase activity. Lipoxin A4 (LXA4) and Lipoxin B4 (LXB4) biosynthesis has been detected in a variety of inflammatory conditions. The native lipoxins LXA4 and LXB4 demonstrate potent antiinflammatory and proresolution bioactions. However, their therapeutic potential is compromised by rapid metabolic inactivation by PG ...