Synthetic Communications®

Amine Salt–Catalyzed Synthesis of 5-Substituted 1 H-Tetrazoles from Nitriles

Y Zhou, C Yao, R Ni, G Yang

Index: Zhou, Yi; Yao, Cheng; Ni, Renjie; Yang, Gaowen Synthetic Communications, 2010 , vol. 40, # 17 p. 2624 - 2632

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Citation Number: 22

Abstract

The [3+ 2] cycloaddition reaction between sodium azide and various organic nitriles proceeds smoothly in the presence of amine salts as catalyst in dimethylformamide. The corresponding 5-substituted 1-H tetrazoles were obtained under mild condition in good to excellent yields. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file.