Convenient syntheses of 2-alkyl (aryl)-4, 5-diphenyloxazoles and 2-alkyl (aryl)-4-phenyloxazoles

W Pei, S Li, X Nie, Y Li, J Pei, B Chen, J Wu, X Ye

Index: Pei, Weiwei; Li, Shaohui; Nie, Xiaoping; Li, Yiwei; Pei, Jian; Chen, Bingzi; Wu, Jie; Ye, Xiulin Synthesis, 1998 , # 9 p. 1298 - 1304

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Citation Number: 37

Abstract

Abstract: The synthetic methods to prepare 2-alkyl (aryl)-4, 5-diphenyloxazoles and 2-alkyl (aryl)-4-phenyloxazoles were improved on the basis of a mechanistic study of oxazole formation from α-hydroxy ketones (carboxylic esters of benzoin and phenacyl alcohols). By these methods, seven trisubstituted oxazoles and twelve disubstituted oxazoles of the title compounds were prepared. Key words: benzoin carboxylate, phenacyl carboxylate, di- ...