Synthesis of a purine acyclonucleoside series having pronounced antiviral activity. The glyceropurines

KK Ogilvie, N Nguyen-Ba, MF Gillen…

Index: Ogilvie; Nguyen-Ba; Gillen; et al. Canadian Journal of Chemistry, 1984 , vol. 62, # 2 p. 241 - 252

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Citation Number: 66

Abstract

The synthesis of a series of purine analogues of the acyclonucleoside compound A*(A-Star, 1) is described. Compounds in this series have been shown to have pronounced activity against herpesviruses. These compounds have been designated" the glycerosides". The glyceropurines are described in this report. Nucleotides have been constructed containing glyceroadenine (A*, compound 1). These nucleotides are resistant to degradation by ...