Development, Scope and Mechanisms of Multicomponent Reactions of Asymmetric Electron??Deficient Alkynes with Amines and Formaldehyde

…, X Wang, H Jiang, Q Zhu, M Zhang…

Index: Cao, Hua; Wang, Xiujun; Jiang, Huanfeng; Zhu, Qiuhua; Zhang, Min; Liu, Haiyang Chemistry - A European Journal, 2008 , vol. 14, # 36 p. 11623 - 11633

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Citation Number: 47

Abstract

Abstract Based on the reactive behaviour of the substrates, two synthetic routes to polysubstituted pyrimidine derivatives are presented herein: 1) A catalyst-free multicomponent reaction of electron-deficient alkynes, aliphatic amines and formaldehyde and 2) Ag I-catalyzed synthesis of pyrimidines from electron-deficient alkynes, anilines and formaldehyde by a domino reaction. Under optimized conditions, the multicomponent ...