Direct Catalytic Asymmetric Three??Component Kabachnik–Fields Reaction

X Cheng, R Goddard, G Buth…

Index: Cheng, Xu; Goddard, Richard; Buth, Gernot; List, Benjamin Angewandte Chemie - International Edition, 2008 , vol. 47, # 27 p. 5079 - 5081

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Citation Number: 119

Abstract

As mimics of α-amino acids,[1] α-amino phosphonates have great promise as antibacterial [2] and anti-HIV [3] agents as well as protease inhibitors.[4, 5] Consequently, their enantioselective synthesis, in particular by catalytic enantioselective hydrophosphonylation of preformed imines, has attracted considerable interest.[6, 7] Both chiral metal complexes [8] as well as organic catalysts such as Jacobsen s chiral thiourea derivatives,[9] chiral ...