Structure-activity studies of 6-(tetrazolylalkyl)-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 1. Effects of stereochemistry, chain …

…, PS Borromeo, CW Lugar, JD Leander…

Index: Ornstein; Arnold; Allen; Bleisch; Borromeo; Lugar; Leander; Lodge; Schoepp Journal of Medicinal Chemistry, 1996 , vol. 39, # 11 p. 2232 - 2244

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Citation Number: 39

Abstract

A series of 6-substituted decahydroisoquinoline-3-carboxylic acids were prepared as excitatory amino acid (EAA) receptor antagonists. These compounds are antagonists at the N-methyl-d-aspartate (NMDA) and 2-amino-3-(5-methyl-3-hydroxyisoxazol-4-yl) propanoic acid (AMPA) subclasses of ligand gated ion channel (ionotropic) EAA receptors.(3 S, 4a R, 6 R, 8a R)-6-(2-(1 H-tetrazol-5-yl) ethyl)-1, 2, 3, 4, 4a, 5, 6, 7, 8, 8a-decahydroisoquinoline-3 ...