Experimental chemotherapy of tuberculosis. III. Ethyl mercaptan and related compounds in tuberculosis

S Kushner, H Dalalian, FL Bach Jr…

Index: Kushner et al. Journal of the American Chemical Society, 1955 , vol. 77, p. 1152,1154

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Citation Number: 15

Abstract

Utilizing the mouse test as an assay method for antituberculous agents, we showed in 1948, 2 the role of nicotinamide and its derivatives in the chemotherapy of tuberculosis. As a sequence to the study of pyridine derivatives, many pyrazine analogs were synthesized which led ultimately to the discovery of pyra~ inamide~~(Aldinamide3b), an effective, clinical, chemotherapeutic agent. Pyrazinamide in combination with isoniazid now ap-

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