General synthesis of retinoids and arotinoids via palladium-catalyzed cross-coupling of boronic acids with electrophiles

A Torrado, S Lopez, R Alvarez, AR de Lera

Index: Torrado; Lopez; Alvarez; De Lera Synthesis, 1995 , # 3 p. 285 - 293

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Citation Number: 30

Abstract

A novel approach to the synthesis of retinoids and arotinoids (including heterocyclic analogs) is described which is based on the thallium-accelerated palladium-catalyzed cross- coupling of boronic acids with a variety of electrophiles (the Suzuki reaction). The recent characterization of the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), 1 which are members of the steroid/retinoid hormone receptor superfamily of ligand- ...