Reductive amination of quinoline n-oxide with aminopyridines and their N-tozyl derivatives

MA Solekhova, YV Kurbatov

Index: Solekhova; Kurbatov Russian Journal of Organic Chemistry, 2002 , vol. 38, # 8 p. 1192 - 1194

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Citation Number: 6

Abstract

Abstract In reaction of quinoline N-oxide with 2-aminopyridine in the presence of tosyl chloride the substrate undergoes reductive amination into 2-pyridyl (2-quinolyl) amine, and with 3-and 4-aminopyridines reductive tosylamination occurs to furnish N-tosyl derivatives of the corresponding 3-and 4-pyridyl (2-quinolyl) amines. N-tosyl derivatives of aminopyridines also react along reductive tosylamination pathway.