Journal of organometallic chemistry

Synthesis and crystallographic characterization of multi-donor N-heterocyclic carbene chelating ligands and their silver complexes: Potential use in pharmaceuticals

JC Garrison, CA Tessier, WJ Youngs

Index: Garrison, Jered C.; Tessier, Claire A.; Youngs, Wiley J. Journal of Organometallic Chemistry, 2005 , vol. 690, # 24-25 p. 6008 - 6020

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Citation Number: 69

Abstract

The potential for N-heterocyclic carbenes (NHCs) to be used as novel chelating ligands for bio-inorganic pharmaceuticals is discussed. In this paper, we design, synthesize and characterize two NHC precursors, 6 and 7, that we believe have potential for use as metal chelators for pharmaceuticals. The NHC precursors are composed of imidazolium and pyridine rings that would form mixed donor NHCs upon metallation with medicinally ...