Developing microcolin A analogs as biological probes

AK Mandal, J Hines, K Kuramochi, CM Crews

Index: Mandal, Amit K.; Hines, John; Kuramochi, Kouji; Crews, Craig M. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 18 p. 4043 - 4047

Full Text: HTML

Citation Number: 18

Abstract

Three microcolin A and B analogs have been synthesized. Their biological activity profiles were evaluated against several cell lines, revealing the existence of a structural determinant whose role in mediating the antiproliferative effect of the microcolins has heretofore gone unrecognized. While previously described as potent immunosuppressive natural products, we found that these microcolin analogs possessed no selective cytotoxicity when ...

Related Articles:

Optical Resolution of Cyclic Amides by Inclusion in Dehydrocholic Acid.

[Bortolini, Olga; Fogagnolo, Marco; Fantin, Giancarlo; Medici, Alessandro Chemistry Letters, 2003 , vol. 32, # 3 p. 206 - 207]

Synthesis of the peptide moiety of the jamaicamides

[Tanaka, Ayano; Usuki, Toyonobu Tetrahedron Letters, 2011 , vol. 52, # 39 p. 5036 - 5038]

Synthesis of the peptide moiety of the jamaicamides

[Tanaka, Ayano; Usuki, Toyonobu Tetrahedron Letters, 2011 , vol. 52, # 39 p. 5036 - 5038]

More Articles...